

Free from animal and human derived products / Fully ACF
During the last decades the regulatory pressure to move away from the use of FBS has become ever bigger since the risk of contaminations with viruses and prions, and the need for traceability records. TNCBio supports the demand for a fully animal component free re- placement for FBS by presenting XerumFree™, an efficient and fully defined cell culture supplement.
The composition of XerumFree™ is guaranteed free from any product derived from animal or human material. XerumFree™ has an ultra low protein content. The proteins in XerumFree™ are from recombinant source only and these proteins are produced by a recombinant bacterial process in ACF media.
Fully defined is the best way to the same quality for every batch.
Many products in the market that are offered as alternatives for FBS are compositions that contain hydrolysates, plant extracts and/or animal or human proteins like albumins. This can affect the consistency from batch to batch in a negative way and lowers the control over the culture environment and makes further rational optimization steps difficult to perform. XerumFree™ consists only of compounds that are each a highly purified chemical from either synthetic, recombinant or plant origin. This guarantees an extremely high consistency from batch to batch and a full traceability record.You can be sure that the XerumFree™ that you use today in your R&D or in your production is exactly the same as the XerumFree™ you will use in the future on short and long term.
There is no need to use special versions for different cell lines.
XerumFree™ works for most mammalian cells, stem cells and primary cells and even insect cells.
Samples have been test over 200 universities, R&D facilities like and even production facilities, XerumFree™ was confirmed to work with:
Liver epithelial cells , Primary human hepatocytes , Primary rat adrenal cells , Primary Human keratinocytes, Stem cells (MSC, ESC, iPSC), CHO, COS monkey cells , VERO monkey kidney cells, HEK 293 , Hybridomas, Per.C6 , HEP G2 cells, NIH 3T3 Balb/c, 3T3, Y1 mouse adrenocortical tumor cell line, PC12 rat pheochromocytoma cells, SH-SY5Y human neuroblastoma cells, HaCaT, HUT78, HeLa , Insect cells
Fully defined is the best way to the same quality for every batch.
The future looks increasingly bio-based, which speeds up the demand for reliable, safe and constant materials in cell culture and cGMP produced XerumFree™ brings you just that. Making sure that your production never faces uncertainties we deliver all our products under cGMP. The production plant is also certified by the Dutch Government for medicinal products, guaranteeing the best quality available. Combined with a proven track record in large volume production this plant is a pharmaceutical control and research laboratory certified by the Dutch Health Authorities for physical and chemical analyses of liquid, semi-solid and solid applications under Good Laboratory Practice. We deliver from our GMP warehouse with full documentation.
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